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    An overview of adreno-cortical fatigue and resulting hyperestrogenism

Caroline D. Levin RN
All rights reserved

When adrenal glands become exhausted by chronic irritation, they no longer produce cortisol. Precursors such as progesterone accumulate and “spilled over” into the adjacent hormone pathway. This results in elevated levels of adrenal estrogen. In other words, when one path is blocked, hormone activity is rerouted down another pathway. A good analogy would be boating down a river. If a dam were built across the river, the water would back up and you would have to steer your boat down a different branch of the river to continue on your trip.


Large, bold text indicates hormones that are being produced in excess. Small or broken arrows indicate a reduction in hormone production.

The signs/symptoms of adrenal estrogen closely resemble those of excess cortisol including, fatigue, confusion, depression, incontinence, irritability, seizures, hyperpigmentation, kidney degeneration, bone marrow and immunoglobulin suppression (anemia, cancer), liver dysfunction, histamine activity (allergies/itching), thyroid binding, hyperlipidemia, and pancreatitis.

Elevated progesterones and androgens —the precursors of estrogen—cause weight gain, heat intolerance (panting), appetite increase, aggression, thick coats, acne (small flesh-colored bumps), and bilateral bald patches.

Severely depleted cortisol causes: anorexia, vomiting, diarrhea, weakness. organ failure and death.


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